Organooxygen compounds
Medchemexpress LLC Ravidasvir hydrochloride | 1303533-81-4 | 99.9% | 835.82 g/mol | C42H52Cl2N8O6 | 10MG
Ravidasvir hydrochloride is a research-grade small-molecule inhibitor of the hepatitis C virus NS5A protein, supplied as the hydrochloride salt for laboratory studies. It exhibits potent, pan-genotypic antiviral activity and is provided with high purity and supporting documentation for use in biochemical and cellular assays.
- Pan-genotypic NS5A inhibitor with potent antiviral activity.
- High purity (99.9%) suitable for research applications.
- Supplied as a hydrochloride salt for improved solubility handling.
- Recommended storage conditions provided to preserve stability.
- Includes product datasheet and safety data sheet for lab use.
Medchemexpress LLC Tiagabine (hydrochloride) | 145821-59-6 | MFCD00892911 | ≥98% | 1 ML
Tiagabine (hydrochloride) is an anticonvulsant agent and a selective inhibitor of the GAT-1 GABA transporter. It potently and selectively inhibits GABA reuptake and demonstrates neuroprotective properties.
- Selective inhibitor of GAT-1 GABA transporter
- Potently and selectively inhibits GABA reuptake
- Exhibits neuroprotective properties
- Protects neurons against mutant huntingtin-induced toxicity
- Increases viability of SH-SY5Y cells
- Inhibits GABA uptake in mouse GAT1 expressed in HEK293 cells
Medchemexpress LLC Nimustine hydrochloride (ACNU) | 55661-38-6 | 98.2% | 309.15 | 1 ML
Nimustine hydrochloride (ACNU) is the hydrochloride salt form of Nimustine. It functions as an alkylating agent by inducing DNA double-strand breaks (DSBs) and inter-strand crosslinks (ICLs), which activates the DNA damage response (DDR) signaling pathway. It also activates the p38 MAPK/JNK signaling pathway and demonstrates antitumor activity.
- Induces DNA double-strand breaks and inter-strand crosslinks.
- Activates DNA damage response signaling.
- Activates p38 MAPK/JNK signaling.
- Demonstrates antitumor activity.
- Exhibits cytotoxicity against human U87MG cells.
- Induces apoptosis in LN-229 cells.
Medchemexpress LLC CCG258208 hydrochloride | 98.1% | 488.94 | 1 MG
CCG258208 (GRK2-IN-1) hydrochloride is a potent and selective GRK2 (G protein-coupled receptor kinase 2) inhibitor (IC50=30 nM). It exhibits 230-fold selectivity over GRK5 and more than 2500-fold selectivity over GRK1, PKA, and ROCK1. This compound can be utilized in heart failure research.
- Potent and selective GRK2 inhibitor (IC50=30 nM).
- Exhibits 230-fold selectivity over GRK5 (IC50=7.09 μM) and more than 2500-fold selectivity over GRK1 (IC50=87.3 μM), PKA, and ROCK1.
- Applicable in heart failure research.
- Significant improvement in βAR-stimulated contractility in mouse cardiomyocytes at concentrations as low as 0.1 μM.
- Superior half-life in vivo with total plasma drug levels exceeding the GRK2 IC50 for seven hours after a single intraperitoneal administration of 10 mg/kg in CD-1 mice.
Medchemexpress LLC Lidocaine hydrochloride hydrate | 6108-05-0 | 99.8% | 50 MG
Lidocaine hydrochloride hydrate is a sodium channel blocker that inhibits sodium channels with complex voltage and use dependence. It decreases the growth, migration, and invasion of gastric carcinoma cells by up-regulating miR-145 expression and inactivating the MEK/ERK and NF-κB signaling pathways. This amide derivative shows potential for research into ventricular arrhythmia.
- Inhibits sodium channels
- Decreases growth, migration, and invasion of gastric carcinoma cells
- Upregulates miR-145 expression
- Inactivates MEK/ERK and NF-κB signaling pathways
- Decreases cell proliferation and viability in MKN45 cells
- Increases apoptotic cell rate in MKN45 cells
- Down-regulates Cyclin D1 and up-regulates p21 expression in MKN45 cells
Medchemexpress LLC BMY 14802 hydrochloride | 105565-55-7 | MFCD04039786 | 98.0% | 384.85 | C18H23ClF2N4O | 5 MG
BMY-14802 hydrochloride is the hydrochloride salt of a selective and orally active sigma receptor antagonist that also exhibits 5-HT1A agonist and α1-adrenergic activity. It is used in preclinical research exploring antipsychotic effects and movement disorders, and is supplied for research use only.
- Selective sigma receptor antagonist with reported IC50 = 112 nM.
- Also displays 5-HT1A agonist activity and α1-adrenergic effects.
- Supplied for research use only; not for human or veterinary use.
- High purity by HPLC (≈98.0%).
- Available as solid and as a 10 mM solution in DMSO.
- Molecular weight 384.85; formula C18H23ClF2N4O.
Medchemexpress LLC Dyclonine hydrochloride | 536-43-6 | 99.3% | 1 ML
Dyclonine hydrochloride, also known as Dyclocaine hydrochloride, is an orally effective covalent inhibitor of Aldehyde Dehydrogenase (ALDH) that can cross the blood-brain barrier. It demonstrates sensitizing activities for targeted cancer cells and exhibits antibacterial properties. Additionally, Dyclonine hydrochloride functions as a local anesthetic, capable of suppressing or relieving pain by blocking the transmission of nerve impulses and inhibiting the sensation of touch and pain.
- Orally effective ALDH covalent inhibitor
- Crosses the blood-brain barrier
- IC50 of 35 μM for ALDH2 and 76 μM for ALDH3A1
- Sensitizes targeted cancer cells
- Possesses antibacterial activity
- Acts as a local anesthetic to suppress and relieve pain
- Blocks the transmission of nerve impulses
- Inhibits the sensation of touch and pain
Medchemexpress LLC Claramine hydrochloride | 1430194-56-1 | 99.1% | 625.45 g/mol | C37H73ClN4O | 10 MG
Claramine hydrochloride is a steroidal polyamine research compound reported to cross the blood-brain barrier and to modulate lipid membrane properties. It is supplied as a powder for laboratory research use only.
- Molecular formula: C37H73ClN4O.
- Molecular weight: 625.45 g/mol.
- Cas number: 1430194-56-1.
- Form: powder, white to off-white solid.
- Purity: 99.1% (HPLC, batch certificate of analysis).
- Solubility: DMSO 2.2 mg/mL (3.52 mM; ultrasonic warming to 60°C recommended).
- Storage: powder -20°C (up to 3 years) or 4°C (up to 2 years); in solvent -80°C (up to 6 months).
- Intended use: for research use only, not for human or clinical applications.
Medchemexpress LLC Vimirogant hydrochloride | 1802678-42-7 | 98.4% | 552.65 g/mol | C27H35F3N4O3S·xHCl | 1 MG
- Selective RORγt inhibition: Ki = 3.5 nM and IC50 = 17 nM.
- Reduces IL-17A secretion in multiple cell assays (reported IC50 values).
- High purity suitable for research applications (98.39%).
- Solid, light yellow appearance for ease of handling and storage.
- Storage stability: keep at 4°C, sealed and away from moisture; solvent stability specified for -80°C and -20°C.
Medchemexpress LLC BMY-25368 hydrochloride | 86134-36-3 | ≥97.0% | 379.88 | C19H26ClN3O3 | 10 MG
BMY-25368 hydrochloride is a research reagent used as a histamine H2 receptor antagonist and gastric acid secretion inhibitor. Supplied as a hydrochloride salt with documented molecular and purity data, it is intended for preclinical in vitro and in vivo studies where receptor antagonism or gastric secretion modulation is required.
- Histamine H2 receptor antagonist for gastric acid secretion studies.
- Hydrochloride salt form for improved solubility and stability.
- High purity (≥97.0% by NMR) suitable for research use.
- Verified molecular weight (379.88) and formula for accurate dosing.
- Available in small-scale quantities for preclinical experiments.
Medchemexpress LLC Repinotan hydrochloride | 144980-77-8 | 97.1% | 25 MG
Repinotan hydrochloride (BAY x 3702) is a potent, selective, brain-penetrant, and orally active 5-HT1A receptor agonist with Ki values of 0.19 nM (calf hippocampus), 0.25 nM (rat and human cortex), and 0.59 nM (rat hippocampus). It has a weak affinity for other related receptors and exhibits pronounced neuroprotective effects. It is intended for research use only.
- Potent, selective, brain-penetrant, and orally active 5-HT1A receptor agonist.
- Exhibits pronounced neuroprotective effects.
- Weak affinity for other related receptors.
- For research use only.
